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Foshan Jiazhinuo Biotechnology Co.,Ltd
Foshan Jiazhinuo Biotechnology Co.,Ltd

China Active Pharmaceutical Ingredients Pramipexole CAS 104632-26-0 for Antiparkinsonian manufacturer


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Active Pharmaceutical Ingredients Pramipexole CAS 104632-26-0 for Antiparkinsonian 

Price: 1.0 USD 
Payment Terms: T/T,WU,Money Gram;Bitcoin 
Place of Origin: Guangdong, China (Mainland) 
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Product Detail

Model No.: 13690838732
Production Capacity: 1000kg/month
Delivery Date: 4days
Brand: Nanjian
CAS: 104632-26-0
Means of Transport: Ocean,Land,Air
Packing: 25kg/Drum
Assay: 99%
Apperance: White powder

CBNumber: CB0486178
Molecular formula: C10H17N3S
Molecular weight: 211.33
MOL File: 104632-26-0.mol
Chemical properties of pramipexole

  • uick Details of Active Pharmaceutical Ingredients Pramipexole:

  • Product Name: Pramipexole

    Synonyms: (S)-4,5,6,7-TETRAHYDRO-N6-PROPYL-2,6-BENZOTHIAZOLEDIAMINE;(s)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole;n'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine;pramipexol;(S)-2-Amino-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazoltetrahydrobenzothiazol;PRAMIPEXOLE: PRAMIPEXOLE DIHYDROCHLORIDE;Pramipexol diclorohidrato monohidrato;PRAMIPEXOLE 2HCL MONOHYDRATE;

    MF: C10H17N3S;

    CAS: 104632-26-0;

    MW: 211.33.

    Product name:Pramipexole
    Other Name:(S)-4,5,6,7-TETRAHYDRO-N6-PROPYL-2,6-BENZOTHIAZOLEDIAMINE;(s)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole;n'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine;pramipexol;(S)-2-Amino-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazoltetrahydrobenzothiazol;PRAMIPEXOLE: PRAMIPEXOLE DIHYDROCHLORIDE;Pramipexol diclorohidrato monohidrato;PRAMIPEXOLE 2HCL MONOHYDRATE;
    Molecular formula:C10H17N3S
    Brand nameNJBNSteroid
    Leading timewithin 24 hours upon receipt of payment
    DeliveryFast and secure shipping by EMS, DHL, TNT, FedEx, UPS
    PackageDiscreet and Hidden package according to specific requirement
    AppearanceWhite Powder
    CertificationSGS, ISO 9001, KOSHER
    Payment TermsWestern Union, Money Gram , T/T, Bitcoin
    Minimum Order Quantity10g
    Usage(S)-Pramipexole enantiomer. s disease (PD) and restless legs syndrome (RLS).[1] It is also sometimes used off-label as a treatment for cluster headache and to counteract the problems with sexual dysfunction experienced by some u sers of the selective serotonin reuptake inhibitor (SSRI) antidepressants.
    Molecular structure

  • Brief Introduction of Active Pharmaceutical Ingredients Pramipexole:

  • 1. Pramipexole (Mirapex, Mirapexin, Sifrol) is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS).

    2. Pramipexole has some of the same effects as a chemical called dopamine, which occurs naturally in your body. Low levels of dopamine in the brain are associated with Parkinson's disease.

    3. Only immediate-release pramipexole (Mirapex) is approved to treat either Parkinson symptoms or RLS. Extended-release pramipexole (Mirapex ER) is approved only to treat Parkinson symptoms.

  • Medical Application of Active Pharmaceutical Ingredients Pramipexole:

  • 1. Pramipexole is used to treat symptoms of Parkinson's disease (stiffness, tremors, muscle spasms, and poor muscle control). Pramipexole is also used to treat restless legs syndrome (RLS).

    2. Pramipexole also possesses low/insignificant affinity (500–10,000 nM) for the 5-HT1A, 5-HT1B, 5-HT1D, and α2-adrenergic receptors. It has negligible affinity (>10,000 nM) for the D1, D5, 5-HT2, α1-adrenergic, beta-adrenergic, H1, and mACh receptors. All sites assayed were done using human tissues.

    3. While pramipexole is used clinically (see below), its D3-preferring receptor binding profile has made it a popular tool compound for preclinical research. For example, pramipexole has been used (in combination with D2- and or D3-preferring antagonists) to discover the role of D3 receptor function in rodent models and tasks for neuropsychiatric disorders.

    4. Of note, it appears that pramipexole, in addition to having effects on dopamine D3 receptors, may also affect mitochondrial function via a mechanism that remains less understood. A pharmacological approach to separate dopaminergic from non-dopaminergic (e.g. mitochondrial) effects of pramipexole has been to study the effects of the R-stereoisomer of pramipexole (which has much lower affinity to the dopamine receptors when compared to the S-isomer) side-by-side with the effects of the S-isomer.

    5. Bipolar Depression:

    In a single controlled study of twenty one patients, pramipexole was found to be highly effective in the treatment of bipolar depression. Treatment was initiated at 0.125 mg three times a day and increased at a rate of 0.125 mg three times a day to a limit of 4.5 mg daily until the patients' condition satisfactorily responded to the medication or they could not abide the side effects. The final average dosage was 1.7 ± 0.9 mg daily. The incidence of hypomania in the treatment group was no greater than in the control group, although the size of the study is too small to determine risks for manic switch.

    6. Unipolar Depression:

    In one controlled study, pramipexole was shown to be efficacious in the treatment of unipolar depression.

  • Technical Test Sheet of Active Pharmaceutical Ingredients Pramipexole:

  • ItemsSpecificationsResults
    AppearanceWhite or off-white powderOff-white powder
    Chemical purity (HPLC)≥99.0%99.81%
    Optical purity(Chiral HPLC)≥99.0%99.95%
    Loss on drying≤ 1.0%0.43%
    Residue on ignition≤ 0.5%0.07%
    Heavy metals≤ 20ppm< 10ppm
    ConclusionAnalysis according to Factory Standards , Conform

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    5.We arrange the shipment according to your requirements.
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    ShippingProvide your addressee info. ( phone number , zip code )
    PackingAccording to different countries and quantity of orders
    Lead TimeArranged within 12 hours upon receipt of your payment
    PhotosPhotos of parcel would be offered to tell apart the steroids in advance
    Delivery TimeUsually 4-6 working days to reach destinations
    Tracking numberOffered once it is released on the Net .Normally within 24hours upon the receipt of payment.
    After-sale service24/7 online for problems and concern related to steroids

  • Our Mission

  • 1.High quality and standard

  • Standard: Enterprise Standard;

  • All Purity≥98%;

  • We are manufacturer and can provide high quality products with factory price.

  • 2. Fast and safe delivery:

  • Parcel can be sent out within 24 hours after payment. Tracking number available;

  • Secure and discreet shipment. Various transportation methods for your choice;

  • Customs pass rate ≥99%;

  • We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.

  • 3.Service

  • Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.

  • Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.

  • High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

Ms. Sunny
skype Ms. Sunny
Sales Manager
Tel: 86-757-82035343
Mobile: 136 9083 8732
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Company Info

Foshan Jiazhinuo Biotechnology Co.,Ltd [China (Mainland)]

Business Type:Manufacturer, Trading Company
City: Foshan
Province/State: Guangdong
Country/Region: China (Mainland)

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