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Foshan Jiazhinuo Biotechnology Co.,Ltd
Foshan Jiazhinuo Biotechnology Co.,Ltd

China Tenofovir disoproxil fumarate CAS 202138-50-9 Intermediate manufacturer

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Tenofovir disoproxil fumarate CAS 202138-50-9 Intermediate 

Price: 1.0 USD 
Payment Terms: T/T,WU,Money Gram;Bitcoin 
Place of Origin: Guangdong, China (Mainland) 
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Product Detail

Means of Transport: Ocean,Land,Air
Packing: 25kg/Drum
Production Capacity: 1000kg/month
Delivery Date: 4days

Original: China
CAS: 202138-50-9
Molecular formula: C23H34N5O14P
Molecular Weight: 635.51
Purity: 99%
Delivery time: within 24 hours

Profile


Product name: Tenofovir disoproxil fumarate

Other Name Tenofovir disoproxil fumarate;TENOFOVIR DISOPROXIC;9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine fumarate;2,4,6,8-Tetraoxa-5-phosphanonanedioic  , 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)-;Aids031697;Aids-031697;Bis(neopentyloc)pmpa;Tenofovir diisoproxil fuMarate 

Original: China 

CAS: 202138-50-9 

Molecular formula: C23H34N5O14P 

Molecular Weight: 635.51 

Purity: 99% 

Delivery time: within 24 hours upon receipt of payment 


Description


Tenofovir is used in combination with other medicines for the treatment of the infection caused by the human immunodeficiency virus (HIV). HIV is the virus that causes acquired immunodeficiency syndrome (AIDS).


Application


Tenofovir is hardly absorbed through the gastrointestinal tract, for this reason, prodrug of Tenofovir has been developed by esterification, and then to make tenofovir fumarate ester. Tenofovir ester is water-soluble, can be rapidly absorbed and degraded into the active tenofovir, and then was metabolized to the active Tenofovir disoproxil. 


Tenofovir will reach the peak of plasma Concentration within 1-2 h after administration. When combined with food service, the bioavailability of Tenofovir can be increased by 40%. Intracellular half-life of Tenofovir disoproxil is about 10 h, it needs dosing everyday. Because Tenofovir is not a CYP-450 substrate, this may decrease the possibility of interactions with other  caused by CYP450. Elimination of Tenofovir is by glomerular filtration and active tubular secretion. Approximately 70% to 80% is recovered in urine as unchanged drug. Elimination half-life is approximately 17 h.


Indications: Tenofovir is indicated for the treatment of HIV, HBV infection. This product also can cooperated with other reverse transcriptase inhibitors for HIV-1 infection and hepatitis B treatment.


Ms. Karry
skype Ms. Karry
Sales Manager
Tel: 86-188-26312629
Fax: 86-0757-82035343
Mobile: 188 2631 2629
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Company Info

Foshan Jiazhinuo Biotechnology Co.,Ltd [China (Mainland)]


Business Type:Manufacturer, Trading Company
City: Foshan
Province/State: Guangdong
Country/Region: China (Mainland)

Karry:   skype

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